General description

Native protein C from human plasma. Sold as a zymogen. Markedly prolongs kaolin-cephalin clotting time of normal plasma. Activated by α-thrombin to serine protease-activated protein C. In its active form, it is a potent anticoagulant that acts through selective inactivation of Factors Va and VIIIa.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Esmon, N.L., et al. 1999. Haematologica 84, 363.

Packaging

100 µg in Plastic ampoule

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM benzamidine, pH 7.4.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Warning

Toxicity: Standard Handling (A)